‘n Groot internasionale studie het bevind jig is ‘n chroniese siekte waar genetika ‘n groot oorsaak is, eerder as die lewenstylkeuses van die lyer.
Gelei deur navorsers van die Universiteit van Otago, het die genoomwye assosiasiestudie, gepubliseer in Nature Genetics, die genetiese inligting van 2,6 miljoen mense ontleed.
Navorsers het saamgevoegde DNS-datastelle van regoor die wêreld ontleed. Ongeveer driekwart van die data was van kliënte van 23andMe, Inc, ‘n direkte-na-verbruiker genetika en voorkomende gesondheidsmaatskappy, wat ingestem het om deel te neem aan die navorsing.
Hulle het gevind dat oorgeërfde genetika ‘n belangrike deel is van hoekom sommige mense jig kry en die meeste ander nie.
Senior skrywer professor Tony Merriman, van Otago se departement mikrobiologie en immunologie, hoop dat die bevindinge sommige van die stigmas rondom jig sal verwyder.
“Jig is ‘n chroniese siekte met ‘n genetiese basis en is nie die skuld van die lyer nie – die mite dat jig deur lewenstyl of dieet veroorsaak word, moet uit die weggeruim word.
“Hierdie wydverspreide mite veroorsaak dat mense wat aan jig lei skaam is daaroor en geneig is om in stilte te ly en nie die dokter te gaan sien om ‘n voorkomende middel te kry wat uraat in die bloed verlaag en hul pyn sal voorkom nie.
“Mense moet verstaan dat alhoewel spesifieke dieetfaktore, soos die eet van rooivleis, jigaanvalle kan veroorsaak, die fundamentele oorsaak hoë uraatvlakke, kristalle in die gewrigte en ‘n immuunstelsel is wat voorberei is om die kristalle ‘aan te val’ – genetika speel ‘n belangrike rol in al hierdie prosesse.”
Die navorsing het ‘n groot aantal immuungene en immuunweë geïdentifiseer wat nuwe teikens en benaderings bied om jigaanvalle te voorkom.
Bron : https://www.otago.ac.nz/news/newsroom/study-busts-myths-about-cause-of-gout
A major international study has found gout is a chronic illness where genetics is a major cause, rather than lifestyle choices of the sufferer.
Led by University of Otago researchers, the genome-wide association study, published in Nature Genetics, analysed the genetic information of 2.6 million people.
Researchers analysed amalgamated DNA data sets from around the world. About three quarters of the data was from customers of 23andMe, Inc, a direct-to-consumer genetics and preventative health company, who consented to participate in research.
They found inherited genetics is an important part of why some people get gout and most others don’t.
Senior author Professor Tony Merriman, of Otago’s Department of Microbiology and Immunology, hopes the findings will remove some of the stigma around gout.
“Gout is a chronic disease with a genetic basis and is not the fault of the sufferer – the myth that gout is caused by lifestyle or diet needs to be busted.
“This widespread myth causes shame in people with gout, making some people more likely to suffer in silence and not go and see the doctor to get a preventive drug that lowers urate in the blood and will prevent their pain.
“People need to understand that while specific dietary factors, such as eating red meat, can trigger gout attacks, the fundamental cause is high urate levels, crystals in the joints, and an immune system primed to ‘attack’ the crystals – genetics plays an important role in all of these processes.”
The research identified a large number of immune genes and immune pathways that provide new targets and approaches for preventing gout attacks.
Source : https://www.otago.ac.nz/news/newsroom/study-busts-myths-about-cause-of-gout